Does physiological Atrial Natriuretic Peptide stimulate lipid mobilization and oxidation in humans?
Physiological concentrations of ANP stimulate lipid mobilization and oxidation, which may contribute to cardiac cachexia in heart failure.
ANP briskly stimulates lipid mobilization and oxidation at plasma concentrations that are encountered in conditions such as heart failure. Natriuretic-peptide induced lipid mobilization might contribute to cardiac cachexia. Drugs that interfere with the natriuretic peptide system should be evaluated for potential metabolic side effects.
Birkenfeld et al. (Wed,) studied this question.