Evaluating the Opioid-Related Adverse Events of Oliceridine Versus Conventional Opioids in Patient-Controlled Analgesia After Thoracoscopic Lung Resection: A Retrospective Cohort Study

Oliceridine use in PCIA was associated with a lower incidence of ORADEs, primarily driven by reduced PONV, compared to conventional opioids. These findings suggest oliceridine may be a safer alternative for postoperative pain management, warranting confirmation in larger prospective randomized trials. This study is among the first to provide a comprehensive comparative analysis of ORADEs between oliceridine and conventional opioids in a real-world PCIA setting, offering valuable insights into optimizing postoperative pain management strategies.