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Vascular Sphingosine Kinase 1 Regulates Angiotensin II–Induced Hypertension | Synapse

April 10, 2026Hypertension0 citations

Vascular Sphingosine Kinase 1 Regulates Angiotensin II–Induced Hypertension

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EJEwelina JózefczukJagiellonian University PSPiotr SzczepaniakJagiellonian University TMTomasz P. MikolajczykJagiellonian University

Key Points

This research aims to explore the role of sphingosine kinase 1 in regulating hypertension induced by angiotensin II.
Investigated the function of sphk1 in smooth muscle cells
Analyzed its effect on myogenic tone
Examined the relationship between sphk1 and angiotensin II in hypertension
Sphk1 significantly modulates myogenic tone when exposed to angiotensin II
Inhibition of sphk1 may reduce hypertension effects induced by angiotensin II.

Abstract

SMC-derived Sphk1 plays a predominant role in AngII-induced HTN by modulating myogenic tone.

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Cite This Study

Józefczuk et al. (Tue,) studied this question.

synapsesocial.com/papers/69d893c96c1944d70ce04bdc https://doi.org/https://doi.org/10.1161/hypertensionaha.125.25480

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