What question did this study set out to answer?

The aim is to explore how CCN5 contributes to muscle homeostasis and prevents age-related muscle loss.

April 10, 2026Open Access

Dual Roles of CCN5/WISP2 in Cytosol and Secretome for Maintaining Muscle Homeostasis and Preventing Sarcopenia

Key Points

The aim is to explore how CCN5 contributes to muscle homeostasis and prevents age-related muscle loss.
Analyzed the effects of CCN5 on muscle cells
Assessed mitochondrial function and interactions
Investigated pathways related to myosteatosis
CCN5 effectively reduces myosteatosis
Promotes mitochondrial biogenesis
Enhances interactions between lipid droplets and mitochondria

Abstract

CCN5 mitigates myosteatosis and counteracts sarcopenia by promoting mitochondrial biogenesis and enhancing LD-Mt interactions through dual pathways, positioning it as a promising therapeutic target for muscle aging and sarcopenia.

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Discussion

Cite this study

Shen et al. (Wed,) studied this question.

synapsesocial.com/papers/69d8946e6c1944d70ce0553e — DOI: https://doi.org/10.1002/jcsm.70282

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Authors

Zile Shen

Shanghai East Hospital

Zhang Liu

Wuhan University

Guowei Huang

Shanghai Tenth People's Hospital

Journals

Journal of Cachexia Sarcopenia and Muscle

Actions

Institutions

Tongji University

Wenzhou Medical University

Shanghai Tenth People's Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Dual Roles of CCN5/WISP2 in Cytosol and Secretome for Maintaining Muscle Homeostasis and Preventing Sarcopenia

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Also consider