Quinoline/Thiazole Compounds as Selective Acetylcholinesterase Inhibitors: Synthesis and Biological Assessment

Key Points

• The aim is to evaluate new quinoline/thiazole compounds as selective inhibitors of acetylcholinesterase.
• Synthesis of quinoline and thiazole derivatives.
• Biological assessment for acetylcholinesterase inhibition.
• Comparison with FDA-approved acetylcholinesterase inhibitors.
• Several compounds show significant inhibition of acetylcholinesterase.
• The new derivatives demonstrate selectivity compared to known inhibitors.
• Potential effectiveness in treating neurodegenerative diseases is suggested.