What question did this study set out to answer?

To assess the prognostic significance of contralateral supraclavicular lymph node metastases in lung cancer and its impact on staging.

April 10, 2026Open Access

The Prognostic Impact of Supraclavicular Lymph Node Metastases in Lung Cancer: Do We Need a Modification of the Current Staging System?

Key Points

To assess the prognostic significance of contralateral supraclavicular lymph node metastases in lung cancer and its impact on staging.
Analysis of stage IIIB non-small cell lung cancer (NSCLC) outcomes based on lymph node involvement.
Comparison of prognosis between contralateral and ipsilateral supraclavicular metastases.
Recommendations for systemic treatment consideration for high-risk patients.
Contralateral metastases indicate worse prognosis than ipsilateral involvement.
Current staging may inadequately classify the risk of these patients.
A reevaluation of staging systems is suggested based on these findings.

Abstract

Contralateral supraclavicular metastases are associated with a worse prognosis compared to ipsilateral involvement in Stage IIIB NSCLC. These findings suggest a need to reevaluate their classification within current staging systems and to consider systemic treatment for these high-risk patients. Phase III randomized controlled trials are needed to validate this observation.

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Authors

Ahmed Sohaib

Menoufia University

Hany Sedeek

Suez Canal University

Mahmoud El Madawie

Armed Forces Hospital

Journals

Asian Pacific Journal of Cancer Prevention

Actions

Institutions

Cairo University

Ain Shams University

Suez Canal University

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Building similarity graph...

Analyzing shared references across papers

The Prognostic Impact of Supraclavicular Lymph Node Metastases in Lung Cancer: Do We Need a Modification of the Current Staging System?

Key Points

Abstract

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Discussion

Authors

Journals

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References and Citations

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