What question did this study set out to answer?

This research aims to evaluate the skin-lightening efficacy of leatherleaf fern extract and serum.

April 10, 2026Open Access

Skin‐Lightening Efficacy of Leatherleaf Fern Extract and a Leatherleaf Fern‐Based Facial Serum In Vitro and Clinical Trial

Key Points

This research aims to evaluate the skin-lightening efficacy of leatherleaf fern extract and serum.
In vitro assays to assess antioxidant effects and melanin biosynthesis inhibition
Clinical trial for evaluating the effectiveness of LFWE-based serum
Measurement of melanin indices pre- and post-treatment
LFWE exhibits strong antioxidant properties
Significant reduction in melanin indices observed in clinical trial participants
Skin-lightening effects confirmed through both in vitro and clinical assessments

Abstract

LFWE exerts excellent antioxidant effects and inhibits the expression of factors involved in melanin biosynthesis, thereby demonstrating skin-lightening effects. Moreover, LFWE-containing serum significantly reduced melanin indices in clinical trials.

Skin‐Lightening Efficacy of Leatherleaf Fern Extract and a Leatherleaf Fern‐Based Facial Serum In Vitro and Clinical Trial

Key Points

Abstract

Cite This Study

Also Consider

Also Consider