Emerging approaches to difficult-to-manage axial spondyloarthritis

Key Points

• The study aims to redefine management strategies for difficult-to-manage axial spondyloarthritis (axSpA) by focusing on mechanistic approaches.
• Shift from a 'next biologic' to a 'right mechanism' treatment paradigm.
• Emphasize pharmacological escalation and novel therapies for treatment-resistant cases.
• Prioritize evidence-based non-pharmacological interventions for the majority of patients.
• Advocates for improved attention to underutilized non-pharmacological treatments.
• Demonstrates the need for multidisciplinary care among the majority of patients.
• Calls for further research to target difficult-to-manage axSpA cohorts.