July 30, 2010Open Access

Cytosolic phospholipase A2alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice

Key Points

Key points are not available for this paper at this time.

Abstract

These results indicate that cPLA2alpha modulates the earliest molecular and injury responses after cerebral ischemia and have implications for the potential clinical use of cPLA2alpha inhibitors.

AIに質問

Bookmark

View Full Paper

Cite This Study

Kishimoto et al. (Fri,) studied this question.

synapsesocial.com/papers/69d8eca0a5ecc596b5d18bbe https://doi.org/https://doi.org/10.1186/1742-2094-7-42

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cytosolic phospholipase A2alpha modulates NMDA neurotoxicity in mouse hippocampal cultures2006 · 13 citations
2Measurement of Local Cerebral Blood Flow with [ 14 C]Iodoantipyrine in the Mouse1988 · 177 citations
3Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N -methyl- <scp>d</scp> -aspartic acid-receptors and phospholipase A 21997 · 287 citations
4Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage1997 · 721 citations
5Cyclooxygenase-2 Does Not Contribute to Postischemic Production of Reactive Oxygen Species2006 · 88 citations

AIに質問

Bookmark

View Full Paper