September 26, 2012Open Access

Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data

Structured PICO

Does postoperative use of non-steroidal anti-inflammatory drugs increase anastomotic leakage in patients after colorectal resection?

Population

Patients with anastomotic leakage requiring reoperation after colorectal resection

Intervention

Postoperative use of non-steroidal anti-inflammatory drugs (diclofenac, cyclo-oxygenase-2 selective NSAIDs)

Outcome

Anastomotic leakagesafety

Postoperative use of diclofenac and COX-2 selective NSAIDs may increase the risk of anastomotic leakage after colorectal resection.

Abstract

Diclofenac treatment could result in an increased proportion of patients with anastomotic leakage after colorectal surgery. Cyclo-oxygenase-2 selective NSAIDs should be used with caution after colorectal resections with primary anastomosis. Large scale, randomised controlled trials are urgently needed.

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Cite This Study

Klein et al. (Wed,) studied this question.

synapsesocial.com/papers/69d8f7c72c87b79b92d18764 https://doi.org/https://doi.org/10.1136/bmj.e6166

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