January 10, 2012Open Access

Inhibition of dendritic cell migration by transforming growth factor-β1 increases tumor-draining lymph node metastasis

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Abstract

These findings provide new evidence that tumor-derived TGF-β1 inhibits migration of DCs from tumors to their draining lymph nodes, and this immunosuppressive effect of TGF-β1 increases the likelihood of metastasis in the affected nodes.

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Imai et al. (Tue,) studied this question.

synapsesocial.com/papers/69d9174216f0d2beeba3c030 https://doi.org/https://doi.org/10.1186/1756-9966-31-3

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