Key points are not available for this paper at this time.
The restriction enzymes Hpa II and Msp I both recognize the sequence 5′-CCGG (C, cytosine; G, guanine). However, Hpa II cuts mouse liver DNA to fragments four times larger than does Msp I. The size of DNA cut by Msp I is close to that predicted from base composition and nearest neighbor analysis. The most probable explanation of these results is that in mouse the site 5′-CCGG is highly methylated.
Singer et al. (Fri,) studied this question.