Is passive myocardial stiffness increased in patients with hypertension and HFpEF compared to those with hypertension alone?
The development of HFpEF in hypertensive patients is associated with increased passive myocardial stiffness driven by changes in both collagen and titin homeostasis.
Hypertension in the absence of HFpEF did not alter passive myocardial stiffness. Patients with HTN(+)HFpEF had a significant increase in passive myocardial stiffness; collagen-dependent and titin-dependent stiffness were increased. These data suggest that the development of HFpEF depends on changes in both collagen and titin homeostasis.
Zile et al. (Sat,) studied this question.