December 23, 2021

How to best monitor bivalirudin anticoagulant effect for ECMO and VAD—Comparison of four assay methods

Does the dTT1:10 assay provide better monitoring of bivalirudin anticoagulant effect compared to other assay methods in pediatric ECLS?

P

Population

Pediatric patients on extracorporeal life support (ECLS), including ECMO and VAD, receiving bivalirudin

I

Intervention

dTT1:10 assay method for monitoring bivalirudin

C

Comparator

Three other assay methods

O

Outcome

Suitability for routine practice (assay variations and cost)surrogate

The dTT1:10 assay is recommended for routine monitoring of bivalirudin in pediatric ECLS due to its reliability and cost-effectiveness.

dTT1:10 appears to be more suitable for routine practice due to fewer variations and lower cost for monitoring bivalirudin in pediatric ECLS.

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