What are the IMT and aPWV values in obese adolescents with type 2 diabetes, and how do they relate to clinical and metabolic risk factors of CVD?
This pilot study aims to evaluate early surrogate markers of atherosclerosis (IMT and aPWV) in obese adolescents with type 2 diabetes to understand early cardiovascular disease progression.
A therosclerotic cardiovascular dis-ease (CVD) is the major cause ofmortality and morbidity in adults with type 2 diabetes (1). The origin of atherosclerosis is early in childhood with progression toward clinically significant lesions in young adulthood (2,3). Carotid artery intimamedia thickness (IMT) and aortic pulse wave velocity (aPWV), ameasure of arterial stiffness, are noninvasive measures of subclinical ath-erosclerosis that have been used as surro-gate measures of cardiovascular events in various adult studies (4–9). Data regard-ing IMT and arterial stiffness in children are limited despite the increasing tide of obesity and type 2 diabetes. Therefore, in this pilot study, we aimed 1) to evaluate IMT and aPWV in obese adolescents with type 2 diabetes and 2) to investigate the relationship between these vascular markers and the clinical/metabolic risk factors of CVD. RESEARCH DESIGN AND
Gungor et al. (Sun,) studied this question.