Do miR-16 and miR-26a sensitize the heart to takotsubo syndrome-like changes following high-dose adrenaline exposure?
Circulating miR-16 and miR-26a may provide a mechanistic link between prior psychological stress and increased susceptibility to takotsubo syndrome.
miR-16 and miR-26a sensitize the heart to TTS-like changes produced by adrenaline. Since these miRs have been associated with anxiety and depression, they could provide a mechanism whereby priming of the heart by previous stress causes an increased likelihood of TTS in the future.
Couch et al. (Mon,) studied this question.