Targeted detection of amino acid profiles in pleural fluid and serum by liquid chromatography-tandem mass spectrometry for estimating the risks of four aetiologies of pleural effusion: a proof-of-concept study | Synapse
April 12, 2026Open Access
Targeted detection of amino acid profiles in pleural fluid and serum by liquid chromatography-tandem mass spectrometry for estimating the risks of four aetiologies of pleural effusion: a proof-of-concept study
Key Points
This study aims to evaluate the feasibility of detecting amino acid profiles in pleural fluid and serum to assess pleural effusion aetiologies.
Used liquid chromatography-tandem mass spectrometry for amino acid detection.
Analyzed samples from pleural fluid and serum.
Explored diagnostic role across four aetiologies of pleural effusion.
Amino acid detection in pleural effusion and serum is feasible.
Detection offers a minor to moderate enhancement in diagnostic capability.
Abstract
This proof-of-concept study finds that AAs detection in pleural effusion and serum is possible and feasible, but currently has a minor to moderate added diagnostic role.