June 15, 2001Journal of Clinical Oncology356 citations
View Full PaperClinicopathologic Re-Evaluation of 100 Malignant Fibrous Histiocytomas: Prognostic Relevance of Subclassification
Structured PICO
Does clinicopathologic subclassification of malignant fibrous histiocytomas provide prognostic information?
P
Population
100 cases of Malignant Fibrous Histiocytomas (MFH)
I
Intervention
Clinicopathologic re-evaluation and subclassification
O
Outcome
Prognostic relevance (aggressiveness)
Subclassification of malignant fibrous histiocytomas is clinically important, as pleomorphic soft tissue sarcomas with myogenic differentiation are significantly more aggressive.
Abstract
This retrospective study confirms that most so-called MFH can be subclassified by defined criteria; it provides evidence that such classification is clinically important. Specifically, pleomorphic STS showing myogenic differentiation are significantly more aggressive, a finding that allows planning future therapeutic trials.