January 8, 2014Open Access

Global target mRNA specification and regulation by the RNA-binding protein ZFP36

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Abstract

ZFP36-RNA target specificities in vivo are quantitatively similar to previously reported in vitro binding affinities. ZFP36 and ELAVL1 bind an overlapping spectrum of RNA sequences, yet with differential relative preferences that dictate combinatorial regulatory potential. Our findings and methodology delineate an approach to unravel in vivo combinatorial regulation by RNA-binding proteins.

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Mukherjee et al. (Wed,) studied this question.

synapsesocial.com/papers/69dccf2c98c6111533e54346 https://doi.org/https://doi.org/10.1186/gb-2014-15-1-r12

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