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In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.
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Xiangxian Zhang
Central South University
Li Liu
Kunming University of Science and Technology
Xia Yuan
Huizhou Central People's Hospital
SHILAP Revista de lepidopterología
Protein & Cell
Sichuan University
State Key Laboratory of Biotherapy
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Zhang et al. (Thu,) studied this question.
synapsesocial.com/papers/69dd50fc7d97b7e86940ccfb — DOI: https://doi.org/10.1007/s13238-019-0653-9