October 19, 2013Open Access

Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response

VZVanessa E. ZannellaUniversity Health Network APAlan Dal PraOntario Institute for Cancer Research HMHala MuaddiUniversity Health Network

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Abstract

Our data demonstrate that metformin can improve tumor oxygenation and response to radiotherapy. Our study suggests that metformin may represent an effective and inexpensive means to improve radiotherapy outcome with an optimal therapeutic ratio.

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Zannella et al. (Sat,) studied this question.

synapsesocial.com/papers/69dd5dd24917c2595e1015b1 https://doi.org/https://doi.org/10.1158/1078-0432.ccr-13-1787

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