June 26, 2006Open Access

The catabolic pathway mediated by Toll‐like receptors in human osteoarthritic chondrocytes

HKHyun Ah KimKeimyung University MCMi‐La ChoCatholic University of Pusan HCHye Young ChoiGyeongsang National University

Key Points

Key points are not available for this paper at this time.

Abstract

We found that TLRs are increased in OA cartilage lesions. TLR-2 and TLR-4 ligands strongly induce catabolic responses in chondrocytes. Modulation of TLR-mediated signaling as a therapeutic strategy would require detailed elucidation of the signaling pathways involved.

AIに質問

Bookmark

View Full Paper

Cite This Study

Kim et al. (Mon,) studied this question.

synapsesocial.com/papers/69de8e2d726bee048db0c841 https://doi.org/https://doi.org/10.1002/art.21951

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Surfactant protein A increases matrix metalloproteinase-9 production by THP-1 cells2003 · 32 citations
2In vivo selective inhibition of mitogen‐activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes2003 · 136 citations
3Chondrocyte apoptosis induced by nitric oxide.1995 · 629 citations
4Toll-like receptors and innate immunity2001 · 4,267 citations
5Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture1994 · 154 citations

AIに質問

Bookmark

View Full Paper