Whole-genome sequence data uncover loss of genetic diversity due to selection

The use of WGS for genetic diversity quantification revealed that selection results in considerable losses of genetic diversity for rare variants. Using WGS instead of SNP chip data to estimate relationships slightly reduced the loss of rare variants, while using 50 K SNP chip data was sufficient to conserve common variants. The loss of rare variants could be mitigated by a few percent (up to 8 %) depending on which method is chosen to estimate relationships from WGS data.