Trimetallic nano trap-mediated glycolytic and mitochondrial metabolism co-inhibition: ATP suppression for enhanced metal ion-interference therapy

Key Points

• This research aims to explore the effects of trimetallic nano traps on both glycolytic and mitochondrial metabolism to inhibit ATP production in cancer therapy.
• Utilized trimetallic nano traps for targeted intervention.
• Assessed effects on glycolysis and mitochondrial function in cancer cells.
• Analyzed ATP levels to measure metabolic suppression.
• Significant ATP suppression was observed in treated cancer cells.
• Co-inhibition of glycolytic and mitochondrial metabolism was confirmed.
• The approach showed potential for enhancing metal ion-interference therapy.