What question did this study set out to answer?

The central aim is to explore how laser interstitial thermal therapy (LITT) affects blood-brain barrier permeability in glioblastoma.

April 17, 2026Open Access

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Laser Interstitial Thermal Therapy Enhances Bidirectional Blood-Brain Barrier Permeability in Glioblastoma

Key Points

The central aim is to explore how laser interstitial thermal therapy (LITT) affects blood-brain barrier permeability in glioblastoma.
Utilized laser interstitial thermal therapy (LITT) on glioblastoma models.
Assessed changes in blood-brain barrier (BBB) integrity after treatment.
Measured levels of circulating tumor DNA (ctDNA) post-LITT.
LITT transiently disrupts the BBB in surrounding areas.
Endothelial junctions show disruption and increased transcytosis following LITT.
Enhanced ctDNA release is observed in conjunction with BBB changes.

Abstract

Our study demonstrates that LITT transiently disrupts the BBB in the periphery of the ablation with endothelial TJ disruption and transcytosis upregulation following distinct time courses. LITT effects on the BBB are bidirectional and enhance ctDNA release in addition to enabling brain entry of agents.

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Laser Interstitial Thermal Therapy Enhances Bidirectional Blood-Brain Barrier Permeability in Glioblastoma

Key Points

Abstract

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