What question did this study set out to answer?

The research aims to compare the effectiveness of susceptibility-guided therapy versus empirical therapy for Helicobacter pylori infection in adults.

April 17, 2026Open Access

Susceptibility‐Guided Versus Empirical First‐Line Therapy of Helicobacter pylori Infection in Adults: A Systematic Review and Meta‐Analysis

Key Points

The research aims to compare the effectiveness of susceptibility-guided therapy versus empirical therapy for Helicobacter pylori infection in adults.
Conducted a systematic review
Performed a meta-analysis of therapy outcomes
Analyzed eradication rates between susceptibility-guided and empirical regimens
Susceptibility-guided therapy has non-inferior, often superior eradication rates compared to empirical regimens.
The benefit of susceptibility testing is reduced where a bismuth quadruple therapy is already standard.

Abstract

In adult first-line therapy, SGT achieves at least non-inferior-and often superior-eradication versus empirical regimens; the incremental benefit is attenuated where BQT is standard. These findings support selective, and increasingly justified, integration of susceptibility testing in settings with clinically relevant resistance.

Susceptibility‐Guided Versus Empirical First‐Line Therapy of Helicobacter pylori Infection in Adults: A Systematic Review and Meta‐Analysis

Key Points

Abstract

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