This study developed an efficient induction system that facilitates the differentiation of SSCs into spinal cord neurons. The system also significantly improved neuronal differentiation and survival under LPS-induced inflammatory conditions. Crucially, the JAK2/STAT3 signaling pathway has been identified as a critical regulatory mechanism in this complex process. Intriguingly, inhibition of the JAK2/STAT3 pathway significantly increases neuronal differentiation efficiency. The transplantation of these differentiated cells resulted in the functional recovery of sensory and motor functions in the lesioned spinal cord. These findings provide a novel therapeutic strategy for stem cell-based treatment of spinal cord injuries and lay both a theoretical and practical foundation for clinical applications.
Guo et al. (Wed,) studied this question.