ABSTRACT Background Iohexol clearance (mGFR ioh ) is a marker of choice for measuring glomerular filtration rate (GFR) in potential living kidney donors. Objectives We studied (1) the determinants of mGFR ioh variation among kidney donors before and 1 year after donation and (2) the impact of donor mGFR ioh change on the gain in estimated GFR 3 months after transplantation in kidney transplant recipients. Methods We performed a retrospective, monocentric study in couples of living kidney donors/transplant recipients. In donors, mGFR ioh was measured before and 1 year after donation and calculated using the slope‐intercept method and the Bröchner‐Mortensen correction. In recipients, eGFR was calculated by the CKD‐EPI formula before and 3 months after transplantation. Determinants of mGFR ioh change in donors and eGFR change in recipients were studied using univariate and multivariate general linear models. Results Sixty‐nine kidney donors (41 women), with a median age of 56 years, were included. The median (10th–90th percentiles) decrease in mGFR ioh at 1 year post‐donation was 29.7% (13.9–43.0). Determinants of a greater mGFR ioh decline (estimate; standard deviation) included female sex (−9.8; 3.3), older age (−0.43; 0.14), and high pre‐donation mGFR ioh value (−0.24; 0.07). Smoking status and body mass index were not associated with mGFR ioh decrease. In kidney recipients, the gain in eGFR CKD‐EPI at 3 months post‐transplantation was not correlated to mGFR ioh variation (before vs. 1 year post‐donation) of donors. Conclusions Our data identified female sex and age as key determinants of mGFR ioh at 1 year post‐donation. Donor mGFR ioh pre‐donation or mGFR ioh change 1 year after donation had no impact on early recipient kidney graft function.
Arrivé et al. (Sun,) studied this question.