Fat reduction mediates the efficacy of intensive lifestyle interventions on fertility‐sparing treatment in overweight patients with endometrial cancer and intraepithelial neoplasia

Key Points

• The aim is to explore how fat reduction affects the success of lifestyle interventions for improving fertility-sparing treatment outcomes in overweight patients.
• Examined the impact of intensive lifestyle interventions on body fat in overweight endometrial cancer patients.
• Focused on fertility-sparing treatment efficacy and body composition metrics.
• ILIs targeting fat reduction significantly improved the efficacy of fertility-sparing treatments.
• Patients exhibited better outcomes when body composition strategies were employed.