What question did this study set out to answer?

This research aims to explore the connection between serum creatinine clearance and cognitive function, focusing on the role of systemic inflammation.

April 24, 2026Open Access

Serum Creatinine Clearance and Cognitive Function in Older Adults: Mediating Effects of Systemic Inflammatory Response Index

Key Points

This research aims to explore the connection between serum creatinine clearance and cognitive function, focusing on the role of systemic inflammation.
Analyzed cognitive performance using CERAD, DSST, and Z-GCP tests in older adults.
Evaluated the association between serum creatinine clearance and cognitive outcomes.
Assessed the mediating effect of systemic inflammatory response index on these associations.
Higher serum creatinine clearance correlates with better cognitive performance in older adults.
Systemic inflammation, represented by SIRI, partially mediates the effect of creatinine levels on cognitive outcomes.

Abstract

Ccr is independently associated with cognitive performance in older adults, particularly in the CERAD, DSST, and Z-GCP domains. Systemic inflammation, as indicated by the SIRI, partially mediates these associations.

Serum Creatinine Clearance and Cognitive Function in Older Adults: Mediating Effects of Systemic Inflammatory Response Index

Key Points

Abstract

Cite This Study

Also Consider

Also Consider