What question did this study set out to answer?

To evaluate the impact of estrogen replacement therapy on physical function and patient-reported outcomes in postmenopausal women with rheumatoid arthritis.

April 27, 2026Lara D. Veeken0 citations

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Estrogen replacement therapy and physical function in rheumatoid arthritis

EMElizabeth Mollard SPSofia PedroThe National Databank for Rheumatic Diseases KMKaleb Michaud

Key Points

To evaluate the impact of estrogen replacement therapy on physical function and patient-reported outcomes in postmenopausal women with rheumatoid arthritis.
Sample included postmenopausal women with rheumatoid arthritis.
Participants received estrogen replacement therapy initiated early postmenopause.
The study assessed physical function and other patient-reported outcomes.
ERT use was associated with improved physical function and patient-reported outcomes.
No observed increase in crude rates of cardiovascular or cancer events during the study.
Greatest benefits of ERT seen when initiated early in postmenopause.

Abstract

ERT use was modestly associated with improved physical function and other PROs in postmenopausal women with RA, with the greatest benefits seen in early postmenopausal initiation. No excess crude rates of cardiovascular or cancer events were observed. Further research is needed to determine the clinical implications of ERT in RA management.

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Estrogen replacement therapy and physical function in rheumatoid arthritis

Key Points

Abstract

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