Serial noninvasive imaging and clinical follow-up in the PESA prospective cohort study will track the progression of early subclinical atherosclerosis in 4,184 asymptomatic middle-aged participants.
Cohort (n=4,184)
The PESA study is an ongoing prospective cohort tracking the progression of subclinical atherosclerosis in asymptomatic middle-aged individuals using noninvasive multiterritorial imaging.
Atherosclerosis starts early in life and progresses silently for decades. Considering atherosclerosis as a "systemic disease" invites the use of noninvasive methodologies to detect disease in various regions before symptoms appear. The PESA-(Progression of Early Subclinical Atherosclerosis) CNIC-SANTANDER study is an ongoing prospective cohort study examining imaging, biological, and behavioral parameters associated with the presence and progression of early subclinical atherosclerosis. Between 2010 and 2014, PESA enrolled 4,184 asymptomatic middle-aged participants who undergo serial 3-yearly follow-up examinations including clinical interviews, lifestyle questionnaires, sampling, and noninvasive imaging assessment of multiterritorial subclinical atherosclerosis (carotids, iliofemorals, aorta, and coronaries). PESA tracks the trajectories of atherosclerosis and associated disorders from early stages to the transition to symptomatic phases. A joint venture between the CNIC and the Santander Bank, PESA is expected to run until at least 2029, and its significant contributions to date are presented in this review paper.
“The long asymptomatic phase of the disease presents a window of opportunity that has not been exploited in the younger population.”
Ibáñez et al. (Thu,) conducted a cohort in Early subclinical atherosclerosis (n=4,184). Noninvasive imaging assessment and clinical follow-up was evaluated on Presence and progression of early subclinical atherosclerosis. Serial noninvasive imaging and clinical follow-up in the PESA prospective cohort study will track the progression of early subclinical atherosclerosis in 4,184 asymptomatic middle-aged participants.
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