Novel 1,2,3-Thiadiazole-based Hydrazone and 1,3,4-Oxadiazole hybrids as promising agents against Streptococcus mutans: Synthesis, biological evaluation, and molecular modeling studies.

Key Points

• This research investigates the development of new agents targeting Streptococcus mutans using thiadiazole and oxadiazole hybrids.
• Synthesis of 1,2,3-thiadiazole-based hydrazones and 1,3,4-oxadiazole hybrids.
• Biological evaluation of synthesized compounds against Streptococcus mutans.
• Molecular modeling studies to assess the interaction of compounds with bacterial targets.
• Identified promising agents with minimal inhibitory concentration of 24.21 ± 0.11 μg/mL.
• Findings indicate potential for multifunctional antibiofilm agents against oral pathogens.