Background: Infectious diseases caused by antibiotic-resistant bacteria pose a significant challenge in healthcare. The development of new antibiotics, while essential, is often hindered by the complexity, cost, and time involved in the process. An alternative approach gaining traction is the conjugation of existing antibiotics with potent antimicrobial agents to improve their efficacy against resistant pathogens. Objective: . Methods: . Results: (39 mm) compared with pure CuO NPs (39 mm, 27 mm, and 41 mm, respectively). The docking results showed that the fosfomycin-conjugated nanoparticle exhibited the highest binding affinity for the biofilm-associated proteins Lec A and Pel A, with docking scores of -4.4 kcal/mol and -4.9 kcal/mol, respectively, compared with blank CuO NPs, supporting their potential application as a novel antimicrobial strategy. Conclusion: This research offers significant insights into the green synthesis of fosfomycin-conjugated nanoparticles for addressing the growing challenge of multidrug-resistant bacterial infections.
Abbasi et al. (Sun,) studied this question.