The Quantitative COPD Exacerbation Recognition Tool (Q-CERT) demonstrated excellent diagnostic performance for identifying acute exacerbations of COPD, with an AUC of 0.956 at a cutoff score of 5.
Cross-Sectional (n=291)
No
Effect estimate: AUC 0.956 (95% CI 0.937-0.976)
p-value: p=<0.001
Objective: There is a need for a patient-centered tool that can quantitatively identify acute exacerbations of COPD. This study aims to develop and validate a digital tool that enables such care by providing a quantifiable severity score. Methods: A total of 161 AECOPD patients and 130 stable COPD patients from Henan Provincial People’s Hospital were enrolled. Demographics, clinical symptoms, pulmonary function parameters and admission laboratory data for patients were collected. The COPD Exacerbation Recognition Tool (CERT) was quantified using a 4-point Likert scale (0– 3) to derive the Quantitative-CERT (Q-CERT) score. Effectiveness of the CERT and Q-CERT in identifying AECOPD was assessed. Results: The CERT demonstrated strong diagnostic performance for recognizing AECOPD, with a sensitivity of 85.7%, specificity of 80.8%, and accuracy of 83.5%. The quantitative Q-CERT score further optimized diagnostic accuracy. At a cutoff of 5 points, the Q-CERT provided optimal sensitivity (89.4%) and specificity (83.8%) combination, with an AUC of 0.956 (95% CI: 0.937– 0.976, P < 0.001). Q-CERT scores were significantly higher in patients with AECOPD than in those with stable COPD (8 vs. 0 points, P < 0.001). Furthermore, elevated Q-CERT scores correlated negatively with pulmonary function parameters, including FEV1%pred, FEV1/FVC, MEF75%pred, MEF50%pred, and MMEF%pred (r = − 0.406 to − 0.358, all P < 0.001), with the strongest associations observed in small airway metrics. Conversely, higher Q-CERT scores showed positive correlations with the neutrophil-to-lymphocyte ratio (NLR) (r = 0.181, P < 0.05) and platelet-to-lymphocyte ratio (PLR) (r = 0.245, P < 0.05). Conclusion: Q-CERT enhanced the original CERT’s ability to identify AECOPD. And total score was correlated with pulmonary function impairment and systemic inflammation, making it an efficient and reliable tool for clinical practice. Keywords: chronic obstructive pulmonary disease, COPD, acute exacerbation, COPD exacerbation recognition tool, CERT, patient-centered monitoring
Zhao et al. (Fri,) conducted a cross-sectional in Chronic Obstructive Pulmonary Disease (COPD) (n=291). Quantitative COPD Exacerbation Recognition Tool (Q-CERT) vs. Stable COPD was evaluated on Diagnostic performance (AUC) of Q-CERT for recognizing AECOPD (AUC 0.956, 95% CI 0.937-0.976, p=<0.001). The Quantitative COPD Exacerbation Recognition Tool (Q-CERT) demonstrated excellent diagnostic performance for identifying acute exacerbations of COPD, with an AUC of 0.956 at a cutoff score of 5.