March 31, 2017Open Access

IL-15 sustains IL-7R-independent ILC2 and ILC3 development

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Abstract

ILC survival in vitro and compensates for IL-7R deficiency, as residual ILCs are depleted in mice lacking both molecules. Collectively, these data demonstrate that siLP ILCs are not completely IL-7R dependent, but can persist partially through IL-15 signalling.

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Robinette et al. (Fri,) studied this question.

synapsesocial.com/papers/69fdf2cf37bfdcfbd750c4e9 https://doi.org/https://doi.org/10.1038/ncomms14601

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Journals

Nature Communications

Institutions

Washington University in St. Louis

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