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May 9, 2026Angewandte Chemie International Edition1 citationsOpen Access

Toward Multi(radio)metalated DNA: Enzymatic Polymerization of Metal‐Chelate‐Modified Deoxyribonucleoside Triphosphates

AWAntonio A. W. L. Wong FBFrançois Bénard DPDavid M. Perrin

Key Points

The research aims to develop a method for enzymatic polymerization of metal-chelate-modified DNA for use in therapeutic applications.
Utilized enzymatic polymerization techniques to modify deoxyribonucleoside triphosphates.
Created multi-metalated structures suitable for radiopharmaceutical development.
Investigated versatility for therapeutic and diagnostic applications.
Demonstrated effective polymerization of metal-chelate-modified nucleotides for metalated DNA.
Established a new platform that enables the development of radiopharmaceuticals with programmable information content.

Abstract

therapy), establishing the potential for using the information content of DNA to create multi-metalated radiopharmaceuticals. This programmable platform establishes a new paradigm for metalated molecular probe development with versatility for potential therapeutic, theranostic, and mass spectrometry-based applications, and potentially generalizable to other metal isotopes based on diagnostic or therapeutic requirements.

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