Selective positive allosteric modulation of β2AR using antibody fragments targeting the third intracellular loop

Key Points

• The aim is to demonstrate the potential of selectively modulating β2AR using antibody fragments targeting its divergent loop region.
• Utilized antibody fragments targeting the third intracellular loop of β2AR.
• Assessed ligand-induced cAMP accumulation.
• Investigated receptor internalization mechanisms.
• Demonstrated increased ligand-induced cAMP accumulation.
• Confirmed selective modulation of β2AR through targeted antibody fragments.