Key points are not available for this paper at this time.
After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo1.1.1pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.
Bychek et al. (Tue,) studied this question.