What question did this study set out to answer?

This research aims to identify tumor-intrinsic mechanisms of immune evasion in microsatellite stable colorectal cancer (CRC).

May 10, 2026Open Access

A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer

Key Points

This research aims to identify tumor-intrinsic mechanisms of immune evasion in microsatellite stable colorectal cancer (CRC).
Investigated T-cell-mediated cytotoxicity in CRC
Examined the role of the WICC-NOTUM axis
Proposed NOTUM as a therapeutic target for overcoming immune resistance
Identified a significant tumor-intrinsic mechanism of immune resistance
Demonstrated that targeting the NOTUM program may enhance immunotherapy effectiveness
Showed the WICC-NOTUM axis influences T-cell responses in CRC.

Abstract

T-cell-mediated cytotoxicity, uncovering a tumor-intrinsic mechanism of immune evasion and nominating the WICC-NOTUM axis as a selective and tractable therapeutic target to overcome immunotherapy resistance in CRC.

A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer

Key Points

Abstract

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