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A phase II study of daratumumab and ibrutinib for relapsed/refractory chronic lymphocytic leukemia | Synapse
May 10, 2026
Open Access
A phase II study of daratumumab and ibrutinib for relapsed/refractory chronic lymphocytic leukemia
RP
Ricardo D. Parrondo
SA
Sikander Ailawadhi
BK
Betsy R. Knopf
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Key Points
This study investigates the effectiveness of daratumumab and ibrutinib in treating relapsed and refractory chronic lymphocytic leukemia.
Phase II clinical trial
Participants with relapsed/refractory chronic lymphocytic leukemia received daratumumab and ibrutinib
Outcomes were assessed based on treatment response rates
Treatment showed improved response rates in patients with relapsed/refractory chronic lymphocytic leukemia
Combination therapy was well tolerated with manageable side effects
Further data on efficacy and survival rates is anticipated
Abstract
A phase II study of daratumumab
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Parrondo et al. (Thu,) studied this question.
synapsesocial.com/papers/6a001ff2c8f74e3340f9b2f1
https://doi.org/https://doi.org/10.1038/s41408-026-01497-9
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