Objectives: Aminoglycoside‑induced ototoxicity is a well‑recognized adverse effect that commonly presents as sensorineural hearing loss. This study investigated hearing damage by administering two doses of Kanamycin, with or without concurrent noise exposure. Auditory function was assessed using auditory brainstem response and cochlear microphonic potential. Materials however, when combined with noise exposure, it produces a synergistic effect resulting in severe hearing loss. In this model of auditory damage, cochlear microphonic measurements are less informative than auditory brainstem response testing, providing a more reliable assessment of both peripheral and central auditory pathway function.
Oroei et al. (Thu,) studied this question.