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In this work, dynamic introduction of bioactive RGD peptide on a matrix was successfully demonstrated via reversible multicovalent interactions within PBA/cis-diol polymeric complexes. These reversible, stable multiple interaction sites, in addition to a long accessible polymeric linker, enabled "reversible" control of cell adhesion by specific biomolecular exchange (e.g., glucose or fructose). This biomolecule-triggered, noninvasive strategy shows great promise for use in real-time biological research and mimics natural biomolecular feedback systems, thus having potential application in medical diagnoses and regenerative medicine.
Pan et al. (Thu,) studied this question.
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