July 1, 2008Seminars in Dialysis160 citations
NON‐CORONARY HEART DISEASE IN DIALYSIS PATIENTS: Hypertrophy and Fibrosis in the Cardiomyopathy of Uremia—Beyond Coronary Heart Disease
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Structured PICO
P
Population
Uremic/dialysis patients
Highlights that noncoronary cardiac pathology, including hypertrophy and fibrosis, is the primary driver of cardiac mortality in uremic patients, rather than coronary events.
Abstract
Cardiac disease is the leading cause of death in uremic patients. In contrast to previous opinion, coronary events account for a relatively small proportion of cardiac deaths, the most common causes being sudden death and heart failure. Against this background the current text will discuss noncoronary cardiac pathology, specifically the pathogenesis and the morphological findings caused by (pathological) cardiac hypertrophy, cardiac interstitial fibrosis and microvascular disease.