Dual-targeting macrophage membrane nanosystem enhances radiotherapy-induced antitumor immunity via synergistic nuclear and mitochondrial DNA damage

Key Points

• The aim is to enhance antitumor immunity during radiotherapy by using a dual-targeting nanosystem that affects both nuclear and mitochondrial DNA.
• Employing a macrophage membrane nanosystem alongside radiotherapy treatment
• Assessing immune-related signaling pathways activated by radiotherapy
• Evaluating the effects on both nuclear and mitochondrial DNA damage
• The combinatorial approach shows a significant increase in immune response compared to radiotherapy alone.
• Enhanced DNA damage is observed in both nuclear and mitochondrial DNA, supporting stronger antitumor immunity.
• Results indicate a higher survival rate in the treated group compared to controls, suggesting improved efficacy.