Ischemic stroke significantly increased the risk of 1-year all-cause death in patients with hypertrophic cardiomyopathy (HR 5.689).
Cohort (n=506)
No
What are the risk factors, clinical features, and outcomes of ischemic stroke in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, older age increases the risk of ischemic stroke, which presents predominantly as cardioembolic or small artery occlusion subtypes and significantly increases the risk of 1-year all-cause mortality.
Effect estimate: HR 5.689 (95% CI 1.784-18.144)
Absolute Event Rate: 18.2% vs 3.3%
p-value: p=0.003
Objective: This study aimed to explore risk factors, clinical features, and prognosis of patients with hypertrophic cardiomyopathy (HCM) complicated by ischemic stroke (IS). Methods: We conducted a retrospective analysis of all HCM patient data and a 1-year follow-up study. Results: = 0.003). Conclusion: Older age is a risk factor for IS occurrence in HCM patients. Patients with HCM complicated by IS had mild or moderate neurologic deficits at disease onset. CE and SAO subtypes predominate in patients with concomitant IS, especially the former. Multiple cortical and subcortical infarctions are their neuroimaging characteristics, mainly involving the anterior circulation or anterior + posterior circulation. Is is a risk factor for all-cause death in HCM patients within 1 year.
Lü et al. (Thu,) conducted a cohort in Hypertrophic cardiomyopathy (n=506). Ischemic stroke vs. No ischemic stroke was evaluated on 1-year all-cause death (HR 5.689, 95% CI 1.784-18.144, p=0.003). Ischemic stroke significantly increased the risk of 1-year all-cause death in patients with hypertrophic cardiomyopathy (HR 5.689).
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