Twelve key challenges in medical machine learning and solutions

The utility of machine learning in biomedicine is being investigated in various contexts, including for diagnostic and interpretive purposes for imaging modalities, quantifying disease risk, and processing text from physician and patient reports. To best facilitate the potential of machine learning, clinicians and computational scientists must inform one another about the nature of their clinical challenges and available methods for solving them, respectively. To this end, clinicians need to critically evaluate machine learning studies conducted to solve relevant problems in medicine. This article serves as a checklist for clinicians to understand and appraise machine learning studies and help facilitate productive conversations between the clinical and data science communities to improve human health.