ABSTRACT To construct a medical wound dressing with a micro‐nano gradient fibers structure with different surface characteristics, polylactic acid (PLA) melt‐blown nonwovens (MBNs) were used as the structural framework of the dressing, bacterial cellulose/polylactic acid (BC/PLA) melt‐blown nonwoven composites (MBNCs) were prepared by using an in situ biocomposite method. BC/PLA MBNCs with different contents of BC were prepared by controlling the fermentation time (6, 12, 18, 24 h). Systematic characterization of the surface morphology, moisture permeability, wettability, mechanical properties, pore size distribution, and biocompatibility of BC/PLA MBNCs was evaluated. It is shown that BC grew on the surface of PLA MBNs and penetrated the fiber pores to create a three‐dimensional network composite structure. As the content of BC increases, the hydrophilicity of the material will gradually increase. When the fermentation time was 18 h, the droplets spread rapidly after contacting with the material for 2 s. The material demonstrated a significant promotion of cell proliferation. Compared with PLA MBNs, the stress at break and Young's modulus of BP 4 increased by 534.5% and 531.9%. This material has high biocompatibility and is a new green and environmentally friendly medical wound dressing.
Zhang et al. (Thu,) studied this question.