This scientific article provides a comprehensive and in-depth analysis of the effects of sleep deprivation on the human body from the perspectives of modern physiology, neurobiology, and pathophysiology. Sleep is considered one of the most essential biological needs of the human organism, playing a crucial role in the restoration of the central nervous system, regulation of energy metabolism, maintenance of hormonal balance, and support of immune function. Special attention is given to circadian rhythms and their role in regulating sleep-wake cycles, as well as the importance of melatonin and hypothalamic mechanisms in maintaining the body’s biological clock. The study thoroughly examines the physiological stages of sleep, including non-rapid eye movement (NREM) and rapid eye movement (REM) sleep, and their significance in memory consolidation, restoration of neuronal connections, and maintenance of cognitive performance. It is demonstrated that sleep is an active biological process during which information processing, neural recovery, and emotional stabilization occur. Particular emphasis is placed on the negative impact of chronic sleep deprivation on the central nervous system. The article discusses impairments in attention, memory, reaction speed, and intellectual performance, as well as the development of anxiety, depression, and emotional instability. Long-term sleep deficiency is shown to contribute to serious neurological and psychological disorders. Furthermore, the article analyzes the effects of sleep deprivation on the cardiovascular system, endocrine regulation, and metabolic processes. Chronic lack of sleep is associated with increased secretion of stress hormones, arterial hypertension, reduced insulin sensitivity, obesity, and diabetes mellitus. The suppression of immune function and increased susceptibility to infectious diseases are also discussed in detail. In conclusion, sleep deprivation is identified as a significant pathophysiological factor that exerts complex negative effects on all body systems and substantially reduces overall health and quality of life.
Muhammaddiyor Kuziboyevich Nishonov (Thu,) studied this question.