Targeting inflammatory and oxidative stress signaling networks may delay the onset of cardiovascular pathologies and serve as a novel treatment paradigm, particularly in HFpEF.
Targeting signaling networks involved in inflammation and oxidative stress may represent a novel therapeutic approach for cardiovascular diseases, especially HFpEF.
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Abstract The complex physiological signal transduction networks that respond to the dual challenges of inflammatory and oxidative stress are major factors that promote the development of cardiovascular pathologies. These signaling networks contribute to the development of age-related diseases, suggesting crosstalk between the development of aging and cardiovascular disease. Inhibition and/or attenuation of these signaling networks also delays the onset of disease. Therefore, a concept of targeting the signaling networks that are involved in inflammation and oxidative stress may represent a novel treatment paradigm for many types of heart disease. In this review, we discuss the molecular mechanisms associated with the physiological responses to inflammation and oxidative stress especially in heart failure with preserved ejection fraction and emphasize the nature of the crosstalk of these signaling processes as well as possible therapeutic implications for cardiovascular medicine.
Zhazykbayeva et al. (Tue,) reported a other. Targeting inflammatory and oxidative stress signaling networks may delay the onset of cardiovascular pathologies and serve as a novel treatment paradigm, particularly in HFpEF.
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